Synthesis of some 1H-pyrazolines bearing benzofuran as biologically active agents

Abstract

The condensation of 5-chloro-3-methyl-2-acetyl benzofuran (1) with aromatic aldehydes in presence of alkali gave 2-cinnamoyl-5-chloro-3-methyl benzofurans (2-6) which reacted with hydrazine hydrate to furnish 5-aryl-3-(5-chloro-3-methyl benzofuran-2-yl)-1H-pyrazolines (7-11). Acetylation and benzoylation of 7-11 offered 1-acetyl and 1-benzoyl pyrazolines (12-21). The invitro antimicrobial activity of the compounds is described.