Synthesis and biological activities of new 5-hydrazino-10-substituted-7H-indolo[2, 3-c]isoquinolines and 1-(10-substituted-7H-indolo[2, 3-c]isoquinolin-5yl)-3,5-disubstituted pyrazoles,-3-methyl pyrazol-5-ones and-3, 5-disubstituted pyrazolines

Abstract

10-Substituted-6H, 7H-indolo[2, 3-c]isoquinolin-5-thiones 2a-c are reacted with hydrazine hydrate to yield the corresponding 5-hydrazino-10-substituted-7H-indolo[2, 3-c]isoquinolines 3a-c. These hydrazines on cyclodehydration with acetyl acetone, ethyl acetoacetate and arylidene acetophenones in acidic medium furnish the respective pyrazoles 4a-c, pyrazolones 5a-c and 3, 5-disubstituted pyrazolines 6a-c. These previously unknown compounds have been screened for their antimicrobial, analgesic and antiinflammatory activities.