Stabilization of DNA-Polycation Complex by Lithium Perchlorate

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DC Field	Value	Language
dc.contributor.author	Mulimani V.H
dc.contributor.author	Day R.A.
dc.date.accessioned	2020-06-12T15:08:22Z	-
dc.date.available	2020-06-12T15:08:22Z	-
dc.date.issued	1987
dc.identifier.citation	Journal of Inorganic Biochemistry , Vol. 31 , 2 , p. 103 - 111	en_US
dc.identifier.uri	10.1016/0162-0134(87)80055-7
dc.identifier.uri	http://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/5624	-
dc.description.abstract	The polycation forms a complex with DNA. The complex was stabilized to thermal denaturation by millimolar concentrations of LiClO4, in the range of 0.1-0.10 M LiClO4. No hyperchromicity was observed in the thermal profiles, and instead, hyperchromicity was observed. The complex showed no significant extrinsic CD band, but showed LiClO4-dependent alterations in the DNA intrinsic bands. It was found that Li+ was primarily responsible for the stabilization of the complex. It is proposed that Li+ stabilization arises through ternary complex formation and that the chaotropic ClO4- catalyzes conversion of less stable DNA-polycation complex into a more stable form. © 1987.	en_US
dc.title	Stabilization of DNA-Polycation Complex by Lithium Perchlorate	en_US
dc.type	Article
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