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DC Field | Value | Language |
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dc.contributor.author | PUROHIT, MG | |
dc.contributor.author | BADIGER, GR | |
dc.contributor.author | KALASKAR, NJ | |
dc.date.accessioned | 2020-06-12T15:08:08Z | - |
dc.date.available | 2020-06-12T15:08:08Z | - |
dc.date.issued | 1995 | |
dc.identifier.citation | INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY , Vol. 34 , 9 , p. 796 - 801 | en_US |
dc.identifier.uri | http://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/5523 | - |
dc.description.abstract | Ethyl-5-O-chloroacetyl-2-methylindole-3-carboxylates (2a-e) have been synthesised by the reaction of ethyl 5-hydroxy-2-methylindole-3-carboxylates (1a-e) with chloroacetyl chloride in dry benzene containing triethylamine. These indoles (2a-e) on condensation with methylpiperazine in dry acetone in the presence of anhydrous K,CO3, afford ethyl 5-O-(4-methylpiperazin-1-ylcetyl)-2-methylindole-3-carboxylates (3a-e). Cmpound's (3a-e) are converted into their oxalate derivatives (4a-e). Indole-3-glyoxylyl. chlorides (6a-e) have been prepared from appropriate indoles (5a-e) by reaction with oxalyl chloride in dry ether. These derivatives on condensation with methylpiperazine yield 3-(4-methyl-1-piperazinylglyoxyl)indoles (7a-e) which are converted into oxalate salts (8a-e). Compounds 4a-e and 8a-e have been screened for their antiserotonin activity. Only compound 4d is found to exhibit antiserotonin activity. | en_US |
dc.publisher | COUNCIL SCIENTIFIC INDUSTRIAL RESEARCH | |
dc.title | SYNTHESIS AND ANTISEROTONIN ACTIVITY OF ETHYL 5-O-(4-METHYLPIPERAZIN-1-YLACETYL)-2-METHYLINDOLE-3-CARBOXYLATE AND 3-(4-METHYL-1-PIPERAZINYL-GLYOXYLYL)INDOLES | en_US |
dc.type | Article | |
Appears in Collections: | 1. Journal Articles |
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