Synthesis of some bis-(1,3,4-oxadiazol-2-yl) methanes of biological and pharmacological interest

Abstract

The condensation of malonyl dicarbohydrazide with aldehydes yields malonyl dicarbohydrazones which underwent oxidative cyclization to give bis-(5,5'-disubstituted-1,3,4-oxadiazol-2-yl)methanes. The antibacterial, antifungal, anthelemintic and anitcatatonic activities of these compounds were studied.