Synthesis of new series of 1,8-bis-(4-aryl amino methyl 1,3,4-oxadiazolyl-5-thion-2-yl) octanes, 1,8-bis-(5-thio acetic/formic acid hydrazide/acetic acid 1,3,4-oxadiazol-2-yl) octanes

Abstract

Sebacic acid dihydrazide on refluxing with alcoholic potassium hydroxide and carbon disulphide afforded 1,8-bis-(1,3,4-oxadiazolyl 5-thione-2-yl) octane(II). Compound (II) on reacting with ethylchloroformate and ethylchloroacetate yielded the liquid esters (III and IV). The esters thus obtained on reacting with hydrazine hydrate afforded 1,8-bis-(5-thioformic/acetic acid hydrazide 1,3,4-oxadiazol-2-yl) octanes (V and VI). The compound (II) on reacting with various aromatic amines with formaldehyde yielded 1,8-bis-(4-aryl amino methyl 1,3,4-oxadiazol-5-thione-2-yl) octanes (VII a-1). The compound (II) on further reacting with chloroacetic acid afforded 1,8-bis-(5-thioacetic acid 1,3,4-oxadiazol-2-yl) octane (VIII).