Please use this identifier to cite or link to this item: http://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/5346
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dc.contributor.authorLondonkar R.L
dc.contributor.authorSonar A
dc.contributor.authorPatil S
dc.contributor.authorPatil S.B.
dc.date.accessioned2020-06-12T15:07:55Z-
dc.date.available2020-06-12T15:07:55Z-
dc.date.issued2000
dc.identifier.citationPharmaceutical Biology , Vol. 38 , 4 , p. 291 - 297en_US
dc.identifier.uri10.1076/1388-0209(200009)3841-AFT291
dc.identifier.urihttp://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/5346-
dc.description.abstractImmature male albino rats, 30 days of age, were treated with 0.3 mg nicotine/100 g body weight either orally or intraperitoneally for 30 days. All the animals were autopsied on the 61(st) day, by which time they were sexually mature. Testis, epididymis, seminal vesicle, prostate gland and vas deferens were dissected out, weighed, and processed for biochemical and histological studies. Weight of testis and accessory sex organs of nicotine treated group was significantly reduced. The total cholesterol content was increased while protein, DNA and RNA contents were decreased. The acid phosphatase content was also decreased whereas that of alkaline phosphatase was increased. The surface epithelial cell height of accessory sex organs was decreased along with secretory activity. No spermatozoan was observed in the cauda epididymis of intraperitoneal nicotine treated rats. The changes in the testis and accessory sex organs may be due to reduced output of pituitary FSH and LH which are important to initiate the spermatogenesis and steroidogenesis. The absence of spermatozoa in the cauda epididymis and reduction in the activities of accessory sex organs indicates the delay caused by nicotine in the attainment of puberty.en_US
dc.publisherSwets en Zeitlinger B.V.
dc.subjectAccessory sex organs
dc.subjectAndrogens
dc.subjectGonadotropins
dc.subjectNicotine
dc.subjectPuberty
dc.subjectTestis
dc.titleNicotine delays puberty in male raten_US
dc.typeArticle
Appears in Collections:1. Journal Articles

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