Synthesis and pharmacological activities of biheterocycles 7-substitutedphenyi-5-(5-substituted-2-phenylindol-3-yl)-1, 4-benzo[b]diazepines

Abstract

5-Substituted-2-phenylindol-3-carboxaldehydes (1a-c) were reacted with substituted acetophenones in ethyleneglycol in presence of piperidine to yield the respective chalcones (3a-r). When these chalcones were reacted in absolute ethanol with orthophenylene diamine produced 7-substitutedphenyl-5-(5?- substituted-2?-phenylindol-3?-yl)-1,4-benzo[b]diazepines (4a-r). The structures of the newly synthesised compounds were elucidated on the basis of analytical and spectral data. These compounds have been screened for analgesic, antiinflammatory and locomotor activities.