Synthesis and biological activities of some 1,3,4-oxadiazoles, thiadiazoles, triazoles and related compounds possessing benzofuran moiety

Abstract

The condensation of 5-chloro-3-methyl-2-benzofuran carbohydrazide (4) with phenylisothiocynate gave 5-chloro-3-methylbenzofuran-2-carbo-N- phenylthiosemicarbazide (5). The cyclisation of 5 under different reaction conditions furnished 1,3,4-oxadiazole, 1,3,4-thiadiazole, 1,2,4-triazole, thiadiazolidinone and thiopyrimidone. Their chemical structures have been assigned by IR, 1HNMR, Mass and elemental analyses. All the compounds synthesized were evaluated for antibacterial and antifungal activity.