Synthesis and antimicrobial activity of 2-(2 ',5 '-substituted indolideneamino-3 '-yl)-4,6-diaryl pyrimidines and 2-[(2 ',5 '-substituted indole-3 '-yl) (phenylazo) methyleneimino]-4,6-diaryl pyrimidines

Abstract

Indole-3-carboxaldehydes (2) on condensation with 2-amino-4,6-diarylpyrimidines (3), gave 2-(2',5'-substituted indolideneamino-3'-yl)-4,6-diaryl pyrimidines (4). Compounds 4 on coupling with benzenediazonium chloride in basic medium gave 2[2',5'-substituted indole-3'-yl] (phenylazo) methyleneimino]-4,6-diaryl pyrimidines (5). The compounds were screened for their antimicrobial activities.