Synthesis of novel naphtho[2,1-b]furo pyrazolyl, isoxazolyl and pyridyl derivatives as potential antimicrobial agents

Abstract

The treatment of chalcones 2a-f with substituted. hydrazines in ethanol results in the formation of 3-(3-aminbnaphtho[2,1-b]fur-2-yl)-5-arylpyrazolines 3a-1. The reaction of these chalcones 2a-f with hydroxylamine hydrochloride in presence of catalytic amount of hydrochloric acid affords 3-(3-aminonaphtho[2,1-b]fur-2-yl)-5arylisoxazolines 4a-f. The synthesis of another biheterocycle, 2-amino-3-cyano-4-aryl-6-(3-aminonaphtho [2, 1-b] fur-2yl)-pyridines 5a-f is accomplished by reacting chalcones 2a-f with malanonitrile in presence of ammonium acetate. All the newly synthesized compounds are characterized by elemental analysis and spectral studies, and evaluated for antimicrobial activity.