Synthesis and pharmacological activities of some 2-arylamino/arylidene hydrazino-4-(5 '-chloro-3 '-methylbenzofuran-2-yl) thiazoles

Abstract

The reaction of 5-chloro-3-methyl-2-bromoacetylbenzofuran 2 with various substituted arylthioureas and arylidene thiosemicarbazides in ethanol gave 2-arylamino/arylidene hydrazino-4-(5'-chloro-3'-methylbenzofuran-2'-yl) thiazoles (3a-h) and (4a-e). The compounds have been screened for their antimicrobial, antiinflammatory and diuretic activity.