SYNTHESIS AND BIOLOGICAL EVALUATION OF BENZOFURO [3,2-d] PYRIMIDINES

Abstract

The reaction of 3-amino-2-benzofurancarboxamide 1 with 3,4,5-trimethoxy benzaldehyde in presence of catalytic quantity of conc hydrochloric acid gave 2-aryl-3, 4-dihydro-4-oxobenzofuran [3,2-d] pyrimidine 2. The nuleophilic displacement reaction of compound 2 with phosphorus oxychloride furnished 2-(3,4,5-trimethoxyphenyl)-3,4-dihydro-4-chlorobenzofuro [3,2-d] pyrimidine 3. Some 2, 4-disubstituted benzofuran [3,2-d] pyrimidine derivatives (4-16) were prepared by the reaction of compound 3 with different reagents. All the synthesized compounds were characterized on the basis of IR, (1)H NMR, mass spectra and analytical data. The compounds synthesized were screened for biological activities.