Synthesis and anti-microbial activity of thiazole substituted coumarins

Abstract

A series of some innovative 7-((4-substituted thiazol-2-yl) metiioxy)-4-memyl-2H-chromen-2-one (4a-d) & (6a-b) were syntiiesized starting from ethyl 2-(4-methyl-2-oxo-2H-chromone-7-yloxy)acetate (la). Reaction of compound (la) with aqueous ammonia yielded 2-(4-methyl-2-oxo-2H-chromomen-7- yloxy)acetamide (2a). Compound (2a) on reaction with P2S5 in dioxane gave 2-(4-methyl-2-oxo-2H-chromomen-7yloxy) ethanethioamide (3a). Reaction of (3a) with different substituted phenacylbromide/ dichloroacetone afforded (4a-d) & (5a). Condensation of (5a) with different secondary amines gave desired compounds (6a-b). The newly synthesized compounds are characterized by IR, 1H NMR and mass spectral studies. These synthesized compounds were also screened for their antibacterial and antifungal activities.