SYNTHESIS AND ANTI-MICROBIAL ACTIVITY OF SOME NEW 5-SUBSTITUTED -N-1-[(1E)-(2-CARBOXO-1H QUINOLIN-3-YL) METHYLENE]-3-PHENYL-1H-INDOLE-2-CARBOHYDRZIDE DERIVATIVES

Abstract

Indole and its derivatives occupied a unique place in the chemistry of nitrogen heterocyclic compounds, because of their varied biodynamic properties. New substituted indole Schiff bases 5-substituted -N'-[(1E)-(2-carboxo-1H-quinolin-3-yl)methylene]-3-pheny]-1H-indole-2-carbohydrzide 3a-d are synthesized by condensation of 5-Substituted-3-phenyl-2-carboxahydrazide (0.01 mol) and substituted 3-formyl-2-carboxo-1H-quinolines (0.01 mol) in presence of catalytic amount of the glacial acetic acid. These Schiff bases on further reacting with acetic anhydride/ thioglycolic acid in DMF / FeCl3-AcOH and con Sulphuric acid gives respective pyrrazole 4a-d, thioazolidine 5a-d, 1, 3, 4-oxadiazole 6a-d and oxadiazino 7a-d indole derivatives. All the above synthesized compounds are conformed by spectral data and elemental analysis. The newly synthesized compounds were screened for their antimicrobial activity.