Synthesis and anticonvulsant, antimicrobial activity of some bis-1,3,4-oxadiazole and bis-1,2,4-triazole derivatives from sebacic acid

Abstract

Cyclization of sebacic acid dihydrazide (1) with substituted carboxylic acids (2a-e) using phosphorus oxychloride as cyclizing agent yielded 1,8-bis (5-aryl substituted-1,3,4-oxadiazol-2-yl) octanes (3a-e). These were then reacted with hydrazine hydrate/phenyl hydrazine in ethanol to yield 1,8-bis (5-aryl substituted-4-amino-1,2,4-triazol-3-yl) octanes (4a-e) and 1,8-bis (5-aryl substituted-4-anilino-1,2,4-triazol-3-yl) octanes (5a-e) respectively. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, MS and analytical data. These compounds were screened for anticonvulsant and antimicrobial activity.