Spectrophotometric estimation of cefetamet pivoxil in pharmaceutical formulations

Abstract

Three new simple, sensitive, selective and economical methods (A, B and C) have been developed for the quantitative estimation of cefetamet pivoxil in bulk and its pharmaceutical formulations. Method A is based on the formation of pink coloured chromoges obtained when drug was dizotised with nitrous acid followed by coupling the resulting diazonium salt with diphenylamine exhibiting ?max at 521 nm. Method B is based on the redox reaction of drug with PolinCiocalteau (FC) reagent exhibiting ?max at 675.5 nm. Method C is based on the formation of coloured Schiff base obtained when drug reacted with PDAB (p-dimethylamino-benzaldehyde) to form yellow coloured chromogen exhibiting ?max at 411 nm. These methods obeyed Beer's law in the concentration range of 10-50, 5-25 and 20-100 ?g/mL, respectively. The results of analysis for the 3 methods have been validated statistically and by recovery studies. The results are comparable with those obtained with UV spectrophotometeric method in double distilled water at ?max 234 nm.