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DC Field | Value | Language |
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dc.contributor.author | Goudgaon N.M | |
dc.contributor.author | Basha N.J. | |
dc.date.accessioned | 2020-06-12T15:05:50Z | - |
dc.date.available | 2020-06-12T15:05:50Z | - |
dc.date.issued | 2009 | |
dc.identifier.citation | Indian Journal of Heterocyclic Chemistry , Vol. 18 , 4 , p. 353 - 356 | en_US |
dc.identifier.uri | http://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/4971 | - |
dc.description.abstract | 5-Substituted-2-benzylthiouracil 1(a-c) and 5,6-disubstituted-2- benzylthiouracil 1d on chlorination with POCI 3 gave 5-substituted-4-chloro-2-benzylthiopyrimidines 2(a-c) and 5,6-disubstituted-4- chloro-2-benzylthiopyrimidine 2d respectively. Reaction of 2(a- d) with 2-mercaptobenzimidazole in methanol in presence of anhyd potassium carbonate yielded 2-[(5-substituted-2-benzylthiopyrimidin-4-yl) thio]-1H-benzimidazoles 3. Further, reaction of 2(a-d) with 2-aminobenzimidazole in methanol in presence of pyridine gave 2-[(5-substituted-2-benzylthiopyrimidin-4-yl) amino]-1 H-benzimidazoles 4 in 42-72% yield. The structures of all the synthesized compounds were confirmed by spectroscopic techniques. The synthesized compounds were screened for antibacterial and antifungal activities. | en_US |
dc.title | Synthesis and antimicrobial activitiy of 2-(2-benzylthiopyrimidin-4-yl) substituted benzimidazoles | en_US |
dc.type | Article | |
Appears in Collections: | 1. Journal Articles |
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