SYNTHESIS AND ANTHELMINTIC ACTIVITY OF TRIHETEROCYCLES: [5 '-(5 ''-SUBSTITUTED-3 ''-PHENYLINDOL-2 '-YL)-1 ',3 ',4 '-OXADIAZOL-2 '-YL-THIOMETHYL] BENZIMIDAZOLES

Abstract

Ethyl 5-substituted-3-phenylindol-2-carboxylates (1a-d) were converted to 5-substituted-3-phenylindol-2-carbohydrazides (2a-d), by treating with hydrazine hydrate. Carbohydrazides 2 on reaction with carbon disulphide and potassium hydroxide yielded 5-substituted-3-phenyl-2-(5'-mercapto-1',3',4'-oxadiazol-2'-yl) indoles (3a-d), which on reaction with chloroacetic acid gave 2-(5'-substituted-3'-phenylindol-2'-yl)-1,3,4-oxadiazol-5-thioacetic acids (4a-d). These thioacetic acid derivatives 4 on reaction with orthophenylenediamine dihydrochloride furnished the title compounds 5. Newly synthesized compounds were screened for their anthelmintic activity.