Synthesis of bis[2(4 '-aryl-1 ',2 ',4 '-triazol-5 '-yl)]-3-methoxybenzo-furansulfides and disulfides of biological interest

Abstract

The treatment of 3-methoxy-2-(4'-aryl-3-mercapto-1',2,4'-triazol-5'-yl) benzofurans (1) with thionyl chloride produced the respective bis [2-(4'-aryl-1',2,4'-triazol-5'-yl)-3-methoxybenzofuran] sulphides (2a-c). 1 with ethanolic bromine at room temp gave bis[2-(4'-aryi-1',21,4'-triazol-5'-yl) -3-methoxybenzofuran] disulphides (3a-c). The structural assignment of these sulphides and disulphides was based on earlier observations and analytical and spectral data. The compounds synthesized were found to exhibit appreciable antibacterial activity.