SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 2-[3-SUBSTITUTED-2-THIONE-1,3,4-THIADIAZOLE-5-YL] AMINOBENZOTHIAZOLES

Abstract

Chloro/fluoro substituted-2-aminobenzothiazole (1) was condensed with carbon disulfide and hydrazine hydrate to get (II) which on cyclisation with carbon disulfide in presence of TEA produced (III). Treatment of (III) with formaldehyde and substituted amines gave 2-[3-substituted-2-thione-1,3,4-thiadiazole-5-yl] amino benzothiazoles (IV). All the newly synthesized compounds have been characterized by spectral and elemental analysis. These compounds were screened for antimicrobial, antiinflammatory and analgesic activity; some of them exhibited appreciable activity.