Synthesis and biological activities of indole-3-propionic acids

Abstract

Treatment of 2,5-substituted indoles (1a-f) with acrylic acid in presence of acetic acid and acetic anhydride yielded the desired 2,5-substituted indole-3-propionic acids (2a-f). The structures of compounds were confirmed by IR, NMR and mass spectral data. The newly synthesized compounds were screened for their antiinflammatory activity and analgesic activity. All the compounds of this series showed promising antiinflammatory and analgesic activity. The most active compound of this series was 2f. It was found to be most potent which has shown higher percent of inhibition of oedema and analgesia.