Synthesis, Antimicrobial, and Antioxidant Activities of N-[(5 '-Substituted-2 '-phenyl-1H-indol-3 '-yl)methylene]-5H-dibenzo[b,f]azepine-5-carbohydrazide Derivatives

Abstract

The main aim of the present study was to synthesize new leads with potential antimicrobial and antioxidant activities. As a part of systematic investigation of synthesis and biological activity, some new indole compounds 3a-c and 4a-c were prepared and screened for their antimicrobial and antioxidant activities. The antimicrobial evaluation of newly synthesized compounds was carried out by cup-plate method. Antimicrobial activity results revealed that compound 4a showed promising activity against bacteria Staphylococcus aureus, Klebsiella pneumonia, and Pseudomonas aeruginosa and exhibited maximum inhibition against Aspergillus niger, Aspergillus oryzae, Aspergillus terreus, and Aspergillus flavus. The antioxidant activity was performed by three methods, namely, radical scavenging activity (RSA), ferric ions (Fe+3) reducing antioxidant power (FRAP), and metal chelating activity by using Hatano's, Oyaizu's, and Dinis' methods, respectively. Compound 4a showed promising RSA, FRAP, and metal chelating activity.