Contraceptive effect of Terminalia bellirica (bark) extract on male albino rats

Abstract

To evaluate the contraceptive effect of Terminalia bellirica barks extract in male albino rats. The benzene and ethanol extract of T. bellirica barks at the doses of 10mg and 25mg/100g body weight was administered orally for 50days to adult male albino rats. On day 51, the rats were sacrificed and the testis and accessory reproductive organs were removed and weighed. The organs were processed for biochemical estimation and histological evaluation. The treatment with T. bellirica barks extract resulted in decrease in the weights of testis and accessory reproductive organs. The diameter of testis, somniferous tubules and Leydig cells nuclear were decreased. The spermatogenic elements like, spermatogonia, spermatocytes and spermatids in the testis were reduced significantly as well as sperm count in cauda epididymis. Total cholesterol content is increased while protein and glycogen content were significant reduction in the testis of extracts treated rats compared with the control. T. bellirica barks extract arrest spermatogenesis in male rats without side effects.