Atrophic sulphate induced changes in uterine, adrenal, liver and thyroid gland in female albino rats

Abstract

In the present study, effect of atropine sulphate on uterine cytotoxicity, gravimetric changes, histopathology and biochemical analysis has been evaluated. Three groups of healthy adult female albino rats having six rats in each group were taken. The rats of groups II and III were administered atropine sulphate at the dose level 0.1 mg and 0.2 mg/100 g b.wt., respectively intraperitoneally everyday between 10:00 and 11:00 am for 30 days. However, the rats of group I (control) were given saline alone. After the experimental periods, the rats were sacrificed and the histopathological study of uteri was perfonned. The uterine tissue of the rats of group II and III showed marked vascular congestion, epithelial necrosis and fibrous tissue proliferation. The fibrosis was extensive resulting into compression of endometrial glands. Desquamation of glandular epithehum was also observed. Histometric changes observed in uterine parameters hke diameter, thickness of myometrium and endometrium and surface epithelial cell height were reduced significantly. Biochemical changes are parallel to the gravimetric changes, the protein and glycogen contents are reduced significantly with respective administration of graded dose of atropine sulphate. Although, the gravimetric analysis of adrenal, liver and thyroid gland were increased significantly due to administration of atropine sulphate. © 2009 Academic Journals Inc.