Synthesis and anti-microbial activity of (Z)-4-(4-substituted-thiazol-2-yl)-1-(2-oxoindolin-3-ylidene) semicarbazide and its derivatives

Abstract

3-[(2S)-3-Acetyl-5-amino-N-(4-substituted-thiazol-2-yl)2,3-dihydro-1,3,4-oxadiazol-2-yl]-indolin-2-yl acetates, 1-{N-[(2R)-2-(-2-oxoindolin-3-ylidene)-4-oxo-1,3-thiazolidin-3-yl]-3-(4-substituted-thiazol-2yl)ureas, N-(4-substituted-thiazol-2-yl)-[1,3,4]-oxadiazino[6,5]indol-3-amines and (Z)-4-(4-substituted-thiazol-2-yl)-1-(2-oxo-1-(substituted) methyl)indolin-3-ylidene)semicarbazides have been prepared by making use of (Z)-4-(4-substituted-thiazol-2-yl)-1-(2-oxoindolin-3-ylidene) semicarbazides obtained by the reaction of (4-substituted thiazole-2-yl) semicarbazides and isatin. The structures of the newly synthesized compounds have been confirmed on the basis of analytical, IR, (1)H NMR and mass spectral data. The newly synthesized compounds have been screened for their antimicrobial activities.