Synthesis and antimicrobial activities of novel 5-substituted pyrimidin-2,4,6-triones

Abstract

5-Benzylpyrimidin-2,4,6-triones (3a-c), 5-((furan-2-yl)methyl)pyrimidin-2, 4,6-trione (3g) and 5-((3-aryl-1-phe-nyl-1H-pyrazol-4-yl)methyl)pyrimidin-2,4,6- triones (3h-j) were obtained in two steps. Reaction of barbituric acid (1) with various substituted aromatic aldehydes, furfuraldehyde and 3-aryl-1-phenyl-1H- pyrazole-4-carbaldehydes in methanol yielded the corresponding chalcones 2a-m in 48-85% yield. These chalcones on reduction with sodium borohydride in isopropyl alcohol furnished desired novel compounds 3a-c and 3g-j in 55-85% yield. The structure of all the synthesized compounds have been established by various spectral studies and elemental analysis. All the synthesized compounds have been screened for antimicrobial activity.