Synthesis, characterization, and biological activity of complexes derived from E-N '-(3,4,5-trimethoxybenzylidene)benzofuran-2-carbohydrazide and ortho-phenylenediamine/2,6-diaminopyridine

Abstract

Mixed ligand complexes of the type MLL'Cl2 (where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II), L = ligand derived from the reaction between benzofuran-2-carbohydrazide and 3,4,5-trimethoxybenzaldehyde (TMeOBFC), and L' = ortho-phenylenediamine (opd)/2,6-diaminopyridine (2,6-dap)) have been synthesized. The complexes have been characterized by analytical data, IR, UV-Vis, 1H NMR, DART-MS and ESR spectral data, and magnetic studies. Molar conductance values indicate that the complexes are non-electrolytic in DMF. Antibacterial and antifungal activities of the ligands and complexes have been screened against bacteria Escherichia coli and Staphylococcus aureus and against fungi Aspergillus niger and Aspergillus flavus.