Synthesis and biological activities of pyrazolinobenzofuro [3,2-d] pyridimidines

Abstract

2-(2,4,6-Trimethoxy phenyl/?-naphthyl)-4-hydrazinobenzofuro [3,2-d] pyrimidines 5,6 were prepared by the nuleophilic displacement reaction of 2-(trimethoxy phenyl/?-naphthyl)-4-chlorobenzofuro [3,2-d] pyrimidines 3,4 with hydrazine hydrate in methanol. The reaction of 2-substituted-4- hydrazinobenzofuro [3,2-d] pyrimidines 5,6 with acetyl acetone, ethyl cynoacetate and ethyl acetoacetate in sodium ethoxide furnished pyrazolinobenzofuran [3,2-d] pyrimidines 7-12 respectively. Structures of all newly synthesized compounds were ascertained on the basis of analytical and spectral studies. Further these compounds were evaluated for their antimicrobial and antiinflammatory properties.