Kinetic spectrophotometric determination of sulfa drugs in pharmaceutical formulations

Abstract

Rapid, simple and sensitive kinetic spectrophotometric methods for the determination of some sulfa drugs namely Sulfacetamide Na, sulfadimidine and Sulfanilamide have been developed. The method based on oxidation of each of studied drugs with alkaline potassium permanganate. The reaction is followed spectrophotometrically by measuring the rate of change of absorbance at 526 nm & 610nm. The rate constant and fixed time methods are utilized for construction of calibration graphs to determine the concentration of the studied drugs. The results are validated statistically and checked through recovery studies. The method has been successfully applied for the determination of the studied sulfa drugs in commercial dosage forms.