Evaluation of anti implantation and abortificient properties of Portulaca oleracea L. In albino rats

Abstract

The present study was aimed to evaluate the effect of Portulaca oleracea L on fertility of female albino rats. Albino rats were orally administered with Petroleum Ether, chloroform and Ethanol crude extracts of aerial part of Portulaca oleracea L in both high and low dose (500mg and 250 mg / kg of body weight / day, for 7 days), and effect of crude extract on Anti implantation and Abortificient activity was investigated. The treatment of petroleum ether crude extract has shown 20% and 30% reduction in implantation activity at low (250) and (500) high doses respectively. In case of chloroform and Ethanol crude extracts, the chloroform extract has shown 50% and 60% reduction in implantation activity at low and high doses respectively, whereas Ethanolic crude extracts have shown 40% and 50% reduction in implantation sites with respect to low and high dose of extract treatment. Ethanolic crude extract treatment has shown abortificient activity but the petroleum ether and chloroform extract treatment to pregnant rats did not shown any abortificient activity.