Pharmacological activity of (E) 3-2-(1-(1-hydroxynaphthalen-2-yl) methyleneamino) phenyl) -2-methylquinazoline-4 (3H) -one Schiff base and its transition metal complexes

Abstract

Objectives: To evaluate the biological activity of newly synthesized Schiff base ligand (E) 3-2-(1-(1 hydroxynaphthalen-2-yl) methyleneamino) phenyl) -2 methylquinazoline-4 (3H) -One (HNMAPMQ) and its transition metal complexes. Methods: The newly synthesized ligand (HNMAPMQ) was prepared by the condensation of 3-(2-aminophenyl) -2-methylquinazolin-4 (3H) -one and 2-hydroxy-1-naphthaldehyde. The spectral and structural characterization of the ligand (HNMAPMQ) and its metal complexes were attained by the aid of their elemental analyses and various spectral studies such as IR, 1H NMR and Mass. The biological activities such as antioxidant, antituberculosis and antimicrobial of ligand (HNMAPMQ) and its metal complexes were also studied. Results: According to the analytical and spectroscopic studies the ligand (HNMAPMQ) acts as tridentate ONO donor towards divalent metal ions (Cu (II), Co (II), Ni (II) Mn (II) and Zn (II)) with the involvement of phenolic oxygen, azomethine nitrogen, carboxylato oxygen there by suggesting the octahedral geometry, whereas Zn (II) complex show tetrahedral geometry. The ligand (HNMAPMQ) and its metal complexes shows promising antioxidant activity as compared with Butylated hydroxy anisole (BHA), Tertiary Butylated hydroxyl quinoline (TBHQ) and Ascorbic acid (AA). Similarly the antitubercular activity of ligand (HNMAPMQ) and its metal complexes showed good results. The results obtained from the antimicrobial studies clearly reveals that all the metal complexes show superior activity than the ligand (HNMAPMQ). Conclusion: The newly synthesized ligand (HNMAPMQ) and its metal complexes shows good antioxidant, antitubercular and antimicrobial activities thus can be used as a new drug of choice in the field of pharmacy.