Anti-inflammatory activity of aqueous extract of Ipomoea carnea jacq

Abstract

The aim of present study was to assess the anti-inflammatory activity of aqueous extracts of Ipomoea carnea leaves. Inflammatory diseases including different types of rheumatic diseases are very common throughout the world. Therefore, the search for a better tolerated anti-inflammatory agent appears to be a necessity. Ipomoea carnea is used for the treatment of skin disease in India. Anti-inflammatory activity was screened by carrageenan (0.1%) induced rat paw edema method. The mature green leaves of Ipomoea carnea were collected and authenticated. For screening of anti-inflammatory activity, the extracts were administered orally at a dose of 250 mg/kg and 500 mg/kg body weight. Animals were divided into six groups of 6 animals each. Group 1 served as control and group 2 as reference standard (Etoricoxib 6 mg/kg), group 3 and 4 animals were treated with 250 mg/kg and 500 mg/kg aqueous extract respectively. Paw volume was significantly (p<0.01) reduced in test treated groups (500 mg/kg body weight) as compared to control group. Present study revealed that the plant Ipomoea carnea leaves possesses a significant anti-inflammatory activity as evidences in Carrageenan induced paw edema method.