Synthesis, antioxidant and antimicrobial activities of indolyl pyrazoles

Abstract

3-(2?-Phenyl-5?-substituted 1H-indol-3?-yl)-1-phenylprop- 2-en-1-ones (1) on cyclodehydration with thiosemicarbazide gave 3-(2?-phenyl-5?-substituted-1H-indol-3?-yl)-5-phenyl-4, 5-dihydro-1H-pyrazol-1-thiocarbamides (2). Compounds 2 on cyclocondensation with w-bromoacetophenone yielded compound 3. All the newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR and mass specteromeric studies. The compounds were screened for antioxidant activity and evaluated for antimicrobial activity against various organisms.