Confirmation of quantity of inactive gradients added in the pharma drugs by determining mass attenuation coefficient

Abstract

Analysis is a critical and integral part of the pharma business. Its only upon clearance of products on the analysis can the products be even released into the market. Therefore, analytical methods as well as the involved analytical tools assume prime importance for the qualitative and quantitative test. Hence a non-destructive technique has been developed for the rapid quantitative analysis of active and inactive pharmaceutical ingredients present in the Alprazolam, Famotidine and Diclofenac sodium drug samples by determining mass attenuation coefficient in the low energy (X-ray) region. The x-ray mass attenuation coefficients were studied for above said drug samples at different characteristic x-rays obtained in the energy range from 8 keV to 44 keV from targets viz., Cu, Rb, Mo Ag, Ba and Tb using Am-241 as a primary source of radiation. X-ray intensities were analyzed with and without the attenuator of the each sample using HPGe detector system coupled to multichannel analyzer (MCA) by narrow beam transmission geometry. The obtained mass attenuation coefficient values are compared with the WinXcom values (theoretical). Percentage deviation of WinXCom values and experimental results will signify the quantities of inactive pharmaceutical ingredients are added in the drug samples.