Synthesis characterization and DNA cleavage studies of some transition metal complexes derived from 5-chloro-3-phenyl-N'-(tetrazolo[1,5-a]quinolin-4-ylmethylene)-1H-indole-2-carbohydrazide

Abstract

A series of new coordination complexes of Cu(II), Co(II), Fe(III), Ni(II), Zn(II) and Cd(II), with a new Schiffbase 5-chloro-3-phenyl-N'-(tetrazolo[1,5-a]quinolin-4-ylmethylene)-1H-indole-2-carbohydrazide have been synthesized and characterized by elemental analysis, UV-Visible, IR spectra, 1H NMR spectra, mass spectra, powder X-ray diffraction data, molar conductance, magnetic susceptibility, ESR and TGA. The new Schiffbase has been synthesized by the reaction between 5-chloro-3-phenyl-1H-indole-2-carboxyhydrazide and tetrazolo[1,5-a]quinoline-4-carbaldehyde. The Schiffbase behaves as tridentate ONN donor ligand and forms the complexes of the type ML stoichiometry in case of Cu(II), Co(II), Fe(III), Ni(II), Zn(II) and Cd(II). The Cu(II), Co(II), Ni(II), Zn(II) and Cd(II) complexes have exhibited square pyramidal and Fe(III) exhibited octahedral geometry. The ligand and its metal complexes have been screened for their antibacterial activity against Klebsiella and Pseudomonous aeruginosa, antifungal activity against Aspergillus niger and Aspergillus flavus in minimum inhibitory concentration (MIC) by cup plate method respectively and antioxidant activity by free radical scavenging activity using 1, 1-diphenyl-2-picryl hydrazyl (DPPH), with standard drug vitamin-E and DNA cleavage activity. From this study our newly synthesized ligand and some of its complexes have exhibited good antimicrobial, antioxidant and DNA cleavage activities.