Phytochemical and pharmacological evaluation of Acalypha indica Linn in experimental animal models

Abstract

In the present study the plant was subjected to phytochemical evaluation and anti-inflammatory and analgesic activities by hiring carrageenan induced paw edema, human red blood cells membrane stabilization method (HRBC) as well as animal model of acute inflammation was adopted to probe the possible anti-inflammatory mechanism and eddy’s hot plate and tail flick methods. Polyphenolic extract of Acalypha indica Linn (PPEA) produced significant anti-inflammatory (P < 0.001) and analgesic (P < 0.001) effects in dose dependent manner. The highest levels of phenolics and flavonoids (9.27 mg TA/g and 8.75 mg Ru/g, respectively).The total phenolic and flavonoid content indicates that these compounds are likely to be the main nociceptive and inflammatory contributing to the observed activities. PPEA exhibited significant anti-inflammatory mechanism of chemical constituents may be due, at least in part to the inhibition of PGE2 levels. These finding suggest that of the medicinal herb studied in this paper are good source of inflammations. The results afford evidence to support the traditional linctus abuse of PPEA for the action of inflammation. © 2014-15, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.