La(III) complex involving the O,N-donor environment of quinazoline-4(3H)-one Schiffs base and their antimicrobial attributes against methicillin-resistant Staphylococcus aureus (MRSA)

Abstract

The incidence of methicillin-resistant Staphylococcus aureus increased during the past few decades, so there is an urgent need of new antimicrobial agents if public health is concerned. Though the Schiffs bases and La(III) complex have enormous biological activity, but less attention was given in their synthesis. In the present investigation, we synthesized a new (E)-3-((2-hydroxynaphthalen-1-yl) methyleneamino)-2-methylquinazoline-4(3H)-one HNMAMQ Schiffs base by the condensation of 3-(2-aminophenyl) quinazolin-2-methyl-4(3H)-one and 2-hydroxy-1-naphthaldehyde. The Schiffs base HNMAMQ and its La(III) complex were characterized by elemental analyses, IR, NMR, mass spectra, and thermal studies. The newly synthesized Schiffs base HNMAMQ and its La(III) complex were evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from the Gulbarga region in India. The Schiffs base HNMAMQ and its La(III) complex showed good antimicrobial activity and thus represents a potential new drug of choice. (C) 2014 Elsevier B.V. All rights reserved.