Synthesis, characterization, and biological evaluation of Schiff bases containing indole moiety and their derivatives

Abstract

In the present study series of new Schiff bases containing indole moiety such as N?-[(5-substituted-2-phenyl-1H-indol-3-yl)methylene]-2-oxo-2H-chromene-3-carbohydrazide and their cyclocondensation products N-[2-(5-substituted-2-phenyl-1H-indol-3-yl)-4-oxothiazolidin-3-yl]-2-oxo-2H-chromene-3-carboxamides, 3-[4-acetyl-5-(5-substituted-2-phenyl-1H-indol-3-yl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2H-chromen-2-ones, 3-[5-(5-substituted-2-phenyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-yl]-2H-chromen-2-ones, and 3-chloro-4-(5-substituted-2-phenyl-1H-indol-3-yl)-1-(2-oxo-2H-chromene-3-carbonyl)azetidin-2-ones were prepared. The structures of the newly synthesized compounds have been confirmed on the basis of their elemental analyses, IR, 1H and 13C NMR, and mass spectral studies. These compounds were screened for their antioxidant and antimicrobial activities. Some of the compounds exhibited good antioxidant and antimicrobial activity. Graphical abstract: (Chemical Equation Presented). © 2015 Springer-Verlag.