Synthesis of novel indolyl-thiazolidinone derivatives as antioxidant, antimicrobial and atitubercular agents

Abstract

The present study envisaged the development of novel antioxidant, antimicrobial and antitubercular candidates using the indole scaffold. Several novel indole derivatives (3a-i) were prepared. The structures of these compounds were confirmed by their elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. All the synthesized compounds 3a-i were screened for their in vitro antioxidant activity by various methods such as 1,1-Diphenyl-2- picryl hydrazyl (DPPH) radical scavenging activity (RSA), Ferric ions (Fe3+) reducing antioxidant power (FRAP) and Ferric ions (Fe3+) reducing antioxidant power (FRAP) antimicrobial and antitubercular activities. In vitro antioxidant, antimicrobial and antitubercular activities Compounds 3a and 3c exhibited good RSA and FRAP at a concentration 100 ?g/mL.Compounds 3a and 3c exhibited good metal chelating activity at a concentration 100 ?g/mL. Compound 3a exhibited promising antitubercular activity MIC 3.125 ?g/mL. Compound 3a exhibitted potent antimicrobial activity with MIC 125 ?g/mL against K. pneumonia (NCTC-13368) and Aspergillus terreus (MTCC- 1782). Whereas, the compound 3a exhibited promising antitubrcular activity against mycobacterium tuberculosis (ATCC-2794) with MIC 3.125 ?g/mL.