Synthesis, antimicrobial and antioxidant activities of 2-oxo-6-phenyl-2-yl-4-(2 '-phenyl-5 '-substituted 1H-indol-3 '-yl)-1,2-dihydro pyridin-3-carbonitriles and their derivatives

Abstract

2-Oxo-4-(2 '-phenyl-5 '-substituted 1H-indol-3 '-yl)-6-phenylpyridin-3-carbnitriles (2a-c) and its derivatives containing 1,2,4-triazole (4a-c), thiazolo[3,2-b][1,2,4] triazole (5a-c), hydrazide (6a-c), pyrazolones (7a-c) and (8a-c) were synthesized. Structures of all these previously unknown compounds were confirmed by their spectral studies and elemental analysis. The compounds were screened for their antioxidant and antimicrobial activities. (C) 2011 Production and hosting by Elsevier B. V. on behalf of King Saud University.