Please use this identifier to cite or link to this item: http://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/3998
Title: Synthesis and antimicrobial activity of novel 5-substituted-N-(substituted-2H-[1,3]oxazino[6,5-b]quinolin-3(4H)-y1)-3-phenyl-1H-indole-2-carboxamides
Authors: Basavarajaiah, SM
Mruthyunjayaswamy, BHM
Keywords: Indoles
quinolines
oxazinoquinolines
antimicrobial activity
Issue Date: 2016
Publisher: NATL INST SCIENCE COMMUNICATION & INFORMATION RESOURCES-NISCAIR
Citation: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY , Vol. 55 , 12 , p. 1511 - 1519
Abstract: (E)-5-Substituted-N-[(1,2-dihydro-substituted-2-oxoquinolin-3-yl)methylene]-3-phenyl-/H-indole-2-carbohydrazides 3a-h, obtained by the reaction of 5-substituted-3-phenyl indole-2-carbohydrazides 1a-b and 1,2-dihydro-substituted-2-oxoquinoline-3-carboxaldehydes 2a-d on further reaction with sodium borohydride followed by treatment with formaldehyde have yielded 5-substituted-N-[(1,2-dihydro-substituted-2-oxoquinoline-3-yl)methy1]-3-phenyl-/H-indole-2-carbohydrazides 4a-h and 5-substituted-N-(substituted-2H-[1,3]oxazino[6,5-b]quinolin-3(4B)-yl)-3-phenyl-/H-indole-2-carboxamides 5a-h respectively. Structures of the all the newly synthesized compounds have been confirmed by spectral data. All-these compounds have been screened for their antibacterial activity against Staphylococcus aureus, Escherichia.; coli, Bacillus substilus, antifungal activity against Aspergillus niger and Candida albicans and anti-tuberculods activity against Mycobacterium tuberculosis (H37R(v)).
URI: http://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/3998
Appears in Collections:1. Journal Articles

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