Synthesis and antimicrobial activity of novel 5-substituted-N-(substituted-2H-[1,3]oxazino[6,5-b]quinolin-3(4H)-y1)-3-phenyl-1H-indole-2-carboxamides

Abstract

(E)-5-Substituted-N-[(1,2-dihydro-substituted-2-oxoquinolin-3-yl)methylene]-3-phenyl-/H-indole-2-carbohydrazides 3a-h, obtained by the reaction of 5-substituted-3-phenyl indole-2-carbohydrazides 1a-b and 1,2-dihydro-substituted-2-oxoquinoline-3-carboxaldehydes 2a-d on further reaction with sodium borohydride followed by treatment with formaldehyde have yielded 5-substituted-N-[(1,2-dihydro-substituted-2-oxoquinoline-3-yl)methy1]-3-phenyl-/H-indole-2-carbohydrazides 4a-h and 5-substituted-N-(substituted-2H-[1,3]oxazino[6,5-b]quinolin-3(4B)-yl)-3-phenyl-/H-indole-2-carboxamides 5a-h respectively. Structures of the all the newly synthesized compounds have been confirmed by spectral data. All-these compounds have been screened for their antibacterial activity against Staphylococcus aureus, Escherichia.; coli, Bacillus substilus, antifungal activity against Aspergillus niger and Candida albicans and anti-tuberculods activity against Mycobacterium tuberculosis (H37R(v)).