In vivo aspirn induced peptic ulcer study of Albizzia lebbeck benth in rodents

Abstract

Ethnopharmacological relevance: Albizzia lebbeck Benth (Family Mimoseaceae) is amedicinal plant traditionally used to treat various ailments, including ulcers In order toestablish pharmacological properties of the bark of A lebbeck, studies were performed onantiulcer activity of the plant's methanolic extract. The A slebbeck methanolic extract(ALME) was prepared in the doses of 100, 200 mg/kg. Antiulcer activity of ALME wasevaluated by aspirin induced gastric ulcer. Acute toxicity was also carried out. ALME, atthe dose of 5000 mg/kg, did not cause any signs of toxicity to rats when given orally.Oral administration of ALME exhibited antiulcer activity was supported by histologicalstudies supported the observed antiulcer activity of ALME. This work provides scientificsupport for the antiulcer activities of this plant and thus may find potential applications inthe treatment of ulcer disease. © 2013 by Nova Science Publishers, Inc. All rights reserved.