Synthesis and pharmacological evaluation of substituted-2-triazolo [3,4-b][1,3,4]-thiadiazoles

Abstract

5,6-Dihydro-3-alkyl-6-(5?-substituted-2?-phenylindol- 3?-yl)-s-triazolo[3,4-b][1,3,4]thiadiazoles(2a-h) and 3-substituted-6-(5?-substituted-3?phenylindol-2-yl) -s-triazolo[3,4-b]thiadiazoles (3a-h) have been synthesised by the reaction of 5-alkyl-1-amino-2-mercapto[1,3,4] triazoles (1a-b) with 5-substituted-2-phenylindol-3-carboxaldehydes in dry DMF containing p-toluenesulphonic acid as catalyst and 5-substituted-3-phenylindol-2-carboxylic acids in the presence of phosphorousoxychloride respectively. The structures of the newly synthesised compounds were elucidated on the basis of analytical and spectral data.These compounds have been screened for antimicrobial, antiinflammatory and analgesic activities.