A NEW METHOD FOR THE SYNTHESIS OF 6H,11H-INDOLO[3,2-C]ISOQUINOLIN-5-ONES THIONES AND THEIR REACTIONS

Abstract

The synthesis of 8-substituted and unsubstituted 6H,11H-indolo[3,2-c]isoquinolin-5-ones/thiones 3a-c and 4a-c and their derivatives viz, ethyl (8-substituted-6H,11H-indolo[3,2-c]isoquinolin-5-on-6-yl)acetates 5a-c, (8-substituted-6H,11H-indolo[3,2-c]isoquinolin-5-on-6-yl)acetyl hydrazides 6a-c, 3,5-disubstituted-pyrazoles 7a-c and 8a-c, 3-substituted-pyrazol-5-ones 9a-c and 548-substituted-6H,11H-indolo[3,2-c]isoquinolin-5-on-6-yl)methyl-1,3,4-oxadiazole-2-thiones 10a-c, also ethyl (8-substituted-11H-indolo[3,2-c]isoquinolin-5-ylthio)acetates 11a-c, (8-substituted-11H-indolo[3,2-c]isoquinolin-5-ylthio)acetyl hydrazides 12a-c, 3,5-disubstituted-pyrazoles 13a-c and 14a-c, 3-substituted-pyrazol-5-ones 15a-c and 5-(8-substituted-11H-indolo[3,2-c]isoquin-olin-5-yl)thiomethyl-1,3,4-oxadiazole-2-thiones 16a-c is described.