Synthesis and biological activities of new 3,5-disubstituted-2-(ethyl-5 '-thioxo-1 ',3 ',4 '-oxadiazol-4 '-ethylacetate-2 '-yl)indoles,-2-(5 '-thioxo-1 ',3 ' 4 '-oxadiazol-4 '-methylcarboxyhydrazide-2 '-yl)indoles and -2-(5 '-thioxo-1 ',3 ',4 '-oxadiazol-4 '-alkyl-2 '-yl)indoles

Abstract

3,5-Disubstituted indole-2-carboxylates la-g are reacted with hydrazine hydrate to furnish the corresponding indole-2-carboxyhydrazides 2a-g These on reaction with alkaline carbon disulphide under thermal reaction conditions produce respective 2-(5'-thioxo-1',3',4'-oxadiazol-2'-yl) indoles 3a-g. Reaction of 3a-g with ethyl chloroacetate and alkyl halides in dry acetone and anhyd.K2CO3 yield indoles 4a-g and 6a-r, respectively. Compounds 4a-g on further reaction with hydrazine hydrate in ethanol afforded the compounds 5a-g. Compounds synthesised have been screened for their biological activities.