Please use this identifier to cite or link to this item: http://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/5093
Title: Synthesis and biological evaluation of some N-substituted indoles
Authors: Badiger J
Manjulatha K
Girish M
Sharif A
Purohit M.G.
Keywords: Analgesic activity
Anti-inflammatory activity
N-substituted indole analogues
Synthesis
Issue Date: 2009
Publisher: Arkat
Citation: Arkivoc , Vol. 2009 , 12 , p. 217 - 231
Abstract: The esterification of 1-alkyl/aryl-3-ethoxy carbonyl-5-hydroxy-2-methyl indoles (1a-g) with ethyl chloroacetate and ethyl chloroformate, afforded ethyl 5-(ethoxycarbonyl) methoxy]-1-alkyl/aryl-2-methyl-indole-3-carboxylate (2a-g) and 3-(ethoxycarbonyl)-1-alkyl/aryl-2-methyl-1H-indol-5-yl ethyl carbonate (3a-g) respectively. The reaction of 1b-g with monochloroacetic acid and 2-chloropropionic acid afforded the corresponding indole acetic acid (4b-g) and propanoic acid (5b-g) derivatives respectively. These newly synthesized compounds were evaluated in vivo for potential anti-inflammatory and analgesic activities and the results were compared with indomethacin. These analogues were administered p.o. at a dose level of 20 mg/kg.
URI: 10.3998/ark.5550190.0010.c19
http://gukir.inflibnet.ac.in:8080/jspui/handle/123456789/5093
Appears in Collections:1. Journal Articles

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