Synthesis and evaluation of in vivo antiinflammatory activity of indole-3-acetic acids

Abstract

1,2-Disubstituted-5-methoxyindole/benz(g) indole-3-acetic acids (8a-p) were synthesized from 1-substituted-5-hydroxyindole/benz(g) indole-2-methyl/phenyl-3-carboxylic esters and evaluated for their antiinflammatory activity by paw oedema method in albino rats at a dose of 50 mg/kg and COX-2 enzyme inhibition assay. The structure of all sixteen compounds was confirmed by IR and H-1 NMR spectral data. All the compounds of this series showed promising anti inflammatory activity. The most active compound of this series is 8p. It was found to be most potent which has shown higher percent of inhibition of oedema than the standard drug Diclofenace sodium.