Synthesis and biological evaluation of some new benzofuran derivatives

Abstract

5-Chloro-3-methyl-2-benzofuran carbohydrazide (4) upon treatment with potassium isothiocynate in presence of hydrochloric acid in water gave 5-chloro-3-methylbenzofuran-2-carbo-N-thiosemicarbazide (5). The cyclisation of 5-chloro-3-methylbenzofuran-2-carbo-N-thiosemicarbazide (5) under different reaction conditions offered 1,3,4-oxadiazole, 1,3,4-thiadiazole, 1,2,4-triazole, thiazolidinone and thiopyrimidinone. The structures of these compounds were established on the basis of spectral data. Some of these compounds exhibited good antimicrobial activity.